Pterostilbene Alleviates Cholestasis by Promoting SIRT1 Activity in Hepatocytes and Macrophages

• Main Authors: Chuanrui Ma (Author), Jiaqing Xiang (Author), Guixiao Huang (Author), Yaxi Zhao (Author), Xinyu Wang (Author), Han Wu (Author), Kewei Jiang (Author), Zhen Liang (Author), Lin Kang (Author), Guangyan Yang (Author), Shu Yang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background and purpose: FXR is a promising target for the treatment of human cholestatic liver disease (CLD). SIRT1 is a deacetylase which promotes FXR activity through deacetylating FXR. Pterostilbene (PTE) is an activator of SIRT1. However, the role of PTE in cholestasis has so far not been invest...