Carnosine Stimulates Macrophage-Mediated Clearance of Senescent Skin Cells Through Activation of the AKT2 Signaling Pathway by CD36 and RAGE

• Main Authors: Xuenan Li (Author), Kaiye Yang (Author), Shuang Gao (Author), Jungang Zhao (Author), Guangrong Liu (Author), Yu Chen (Author), Haojie Lin (Author), Wengang Zhao (Author), Zhenlin Hu (Author), Nuo Xu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Macrophages can selectively recognize and eliminate senescent cells, but this function is impaired with age, resulting in excessive accumulation of senescent cells in the skin, which ultimately causes skin aging. Therefore, enhancing the immune surveillance ability of macrophages to clea...