The E3 ubiquitin ligase NEDD4-1 protects against acetaminophen-induced liver injury by targeting VDAC1 for degradation

• Main Authors: Yiwei Zhu (Author), Lin Lei (Author), Xinghui Wang (Author), Linfang Chen (Author), Wei Li (Author), Jinxia Li (Author), Chenchen Zhao (Author), Xiliang Du (Author), Yuxiang Song (Author), Wenwen Gao (Author), Guowen Liu (Author), Xinwei Li (Author)
• Format: Book
• Published: Elsevier, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Acetaminophen (APAP) overdose is a major cause of liver injury. Neural precursor cell expressed developmentally downregulated 4-1 (NEDD4-1) is an E3 ubiquitin ligase that has been implicated in the pathogenesis of numerous liver diseases; however, its role in APAP-induced liver injury (AILI) is uncl...