NRF2 Deficiency Attenuates Diabetic Kidney Disease in Db/Db Mice via Down-Regulation of Angiotensinogen, SGLT2, CD36, and FABP4 Expression and Lipid Accumulation in Renal Proximal Tubular Cells

• Main Authors: Ke Su (Author), Shui-Ling Zhao (Author), Wen-Xia Yang (Author), Chao-Sheng Lo (Author), Isabelle Chenier (Author), Min-Chun Liao (Author), Yu-Chao Pang (Author), Jun-Zheng Peng (Author), Kana N. Miyata (Author), Jean-Francois Cailhier (Author), Jean Ethier (Author), Jean-Baptiste Lattouf (Author), Janos G. Filep (Author), Julie R. Ingelfinger (Author), Shao-Ling Zhang (Author), John S. D. Chan (Author)
• Format: Book
• Published: MDPI AG, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The role(s) of nuclear factor erythroid 2-related factor 2 (NRF2) in diabetic kidney disease (DKD) is/are controversial. We hypothesized that Nrf2 deficiency in type 2 diabetes (T2D) db/db mice (db/db<i>Nrf2</i> knockout (KO)) attenuates DKD progression through the down-regulation of ang...