NRF2 Deficiency Attenuates Diabetic Kidney Disease in Db/Db Mice via Down-Regulation of Angiotensinogen, SGLT2, CD36, and FABP4 Expression and Lipid Accumulation in Renal Proximal Tubular Cells

• Autors principals: Ke Su (Autor), Shui-Ling Zhao (Autor), Wen-Xia Yang (Autor), Chao-Sheng Lo (Autor), Isabelle Chenier (Autor), Min-Chun Liao (Autor), Yu-Chao Pang (Autor), Jun-Zheng Peng (Autor), Kana N. Miyata (Autor), Jean-Francois Cailhier (Autor), Jean Ethier (Autor), Jean-Baptiste Lattouf (Autor), Janos G. Filep (Autor), Julie R. Ingelfinger (Autor), Shao-Ling Zhang (Autor), John S. D. Chan (Autor)
• Format: Llibre
• Publicat: MDPI AG, 2023-09-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

The role(s) of nuclear factor erythroid 2-related factor 2 (NRF2) in diabetic kidney disease (DKD) is/are controversial. We hypothesized that Nrf2 deficiency in type 2 diabetes (T2D) db/db mice (db/db<i>Nrf2</i> knockout (KO)) attenuates DKD progression through the down-regulation of ang...