Linking the Population Pharmacokinetics of Tenofovir and Its Metabolites With Its Cellular Uptake and Metabolism

• Main Authors: K Madrasi (Author), R N Burns (Author), C W Hendrix (Author), M J Fossler (Author), A Chaturvedula (Author)
• Format: Book
• Published: Wiley, 2014-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Empirical pharmacokinetic models are used to explain the pharmacokinetics of the antiviral drug tenofovir (TFV) and its metabolite TFV diphosphate (TFV‐DP) in peripheral blood mononuclear cells. These empirical models lack the ability to explain differences between the disposition of TFV‐DP in HIV‐i...