Photo-induced crosslinked and anti-PD-L1 peptide incorporated liposomes to promote PD-L1 multivalent binding for effective immune checkpoint blockade therapy

• Main Authors: Youngjoo Lee (Author), Sukyung Song (Author), Suah Yang (Author), Jinseong Kim (Author), Yujeong Moon (Author), Nayeon Shim (Author), Hong Yeol Yoon (Author), Sehoon Kim (Author), Man Kyu Shim (Author), Kwangmeyung Kim (Author)
• Format: Book
• Published: Elsevier, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Immune checkpoint blockade (ICB) therapy targeting PD-L1 via monoclonal antibody (mAb) has shown extensive clinical benefits in the diverse types of advanced malignancies. However, most patients are completely refractory to ICB therapy owing to the PD-L1 recycling mechanism. Herein, we propose photo...