In Silico Prediction of Binding Affinities of Hybrid Molecules of Benzothiazole cross-linked with Hydroxamic acid by certain linkers

• Main Authors: yazen alqaysi (Author), Shakir M. Alwan (Author), Ashour H. Dawood (Author)
• 格式: 圖書
• 出版: College of Pharmacy / Mustansiriyah University, 2024-01-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

New hybrid molecules of Benzothiazole cross-linked with hydroxamic acid through an amino acid or aminoalkanoic acid are suggested. All the synthesized hybrid molecules (2A-E) were subjected to molecular docking to evaluate their binding affinities with histone deacetylase enzyme (HDAC8, PDB ID: 1T69...