Deficiency of fibroblast growth factor 21 (FGF21) promotes hepatocellular carcinoma (HCC) in mice on a long term obesogenic diet

• Main Authors: Garima Singhal (Author), Gaurav Kumar (Author), Suzanne Chan (Author), ffolliott M. Fisher (Author), Yong Ma (Author), Hilde G. Vardeh (Author), Imad A. Nasser (Author), Jeffrey S. Flier (Author), Eleftheria Maratos-Flier (Author)
• Format: Book
• Published: Elsevier, 2018-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Non-alcoholic fatty liver (NAFL) associated with obesity is a major cause of liver diseases which can progress to non-alcoholic steatohepatitis, cirrhosis, and hepatocellular carcinoma (HCC). Fibroblast growth factor 21 (FGF21) plays an important role in liver metabolism and is also a pot...