TRPM7 Induces Tumorigenesis and Stemness Through Notch Activation in Glioma

• Main Authors: Jingwei Wan (Author), Alyssa Aihui Guo (Author), Pendelton King (Author), Shanchun Guo (Author), Talib Saafir (Author), Yugang Jiang (Author), Mingli Liu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We have reported that transient receptor potential melastatin-related 7 (TRPM7) regulates glioma stem cells (GSC) growth and proliferation through Notch, STAT3-ALDH1, and CD133 signaling pathways. In this study, we determined the major contributor(s) to TRPM7 mediated glioma stemness by further deci...