Rhein Derivative 4F Inhibits the Malignant Phenotype of Breast Cancer by Downregulating Rac1 Protein

• Main Authors: Xinxiao Li (Author), Yunfeng Liu (Author), Yuhua Zhao (Author), Wei Tian (Author), Lina Zhai (Author), Huifeng Pang (Author), Jiankang Kang (Author), Huaxin Hou (Author), Yanhua Chen (Author), Danrong Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BackgroundTriple-negative breast cancer is a common malignant tumor with unfavorable prognosis affecting women worldwide; thus, there is an urgent need for novel therapeutic drugs with improved anti-tumor activity. Rac family small GTPase 1 (Rac1) plays an important role in malignant behavior and is...