Plasma and Cerebrospinal Fluid Concentrations of Micafungin Administered at High Doses in Critically Ill Infants with Systemic Candidiasis: A Pooled Analysis of Two Studies

• Main Authors: Domenico Umberto De Rose (Author), Iliana Bersani (Author), Maria Paola Ronchetti (Author), Fiammetta Piersigilli (Author), Sara Cairoli (Author), Andrea Dotta (Author), Amit Desai (Author), Laura Lynn Kovanda (Author), Bianca Maria Goffredo (Author), Cinzia Auriti (Author)
• Format: Book
• Published: MDPI AG, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<b>Background</b>: Neonates may require higher doses of micafungin than adults to reach the therapeutic effect for increased plasma clearance. Only poor and inconclusive data are available still now to support this hypothesis, especially with regard to central nervous system micafungin c...