β1 integrins as therapeutic targets to disrupt hallmarks of cancer

• Main Authors: Anne-Florence eBlandin (Author), Guillaume eRenner (Author), Isabelle eLelong-Rebel (Author), Sophie eMartin (Author), Maxime eLehmann (Author), Monique eDontenwill (Author)
• Format: Book
• Published: Frontiers Media S.A., 2015-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Integrins belong to a large family of αβ heterodimeric transmembrane proteins first recognized as adhesion molecules that bind to dedicated elements of the extracellular matrix and also to other surrounding cells. As important sensors of the cell microenvironment, they regulate numerous signaling pa...