Pentamidine rescues contractility and rhythmicity in a Drosophila model of myotonic dystrophy heart dysfunction

• Autors principals: Mouli Chakraborty (Autor), Estela Selma-Soriano (Autor), Emile Magny (Autor), Juan Pablo Couso (Autor), Manuel Pérez-Alonso (Autor), Nicolas Charlet-Berguerand (Autor), Ruben Artero (Autor), Beatriz Llamusi (Autor)
• Format: Llibre
• Publicat: The Company of Biologists, 2015-12-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Up to 80% of individuals with myotonic dystrophy type 1 (DM1) will develop cardiac abnormalities at some point during the progression of their disease, the most common of which is heart blockage of varying degrees. Such blockage is characterized by conduction defects and supraventricular and ventric...