Synthesis, biological evaluation and molecular modelling of 2,4-disubstituted-5-(6-alkylpyridin-2-yl)-1H-imidazoles as ALK5 inhibitors

• Päätekijät: Myoung-Soon Park (Tekijä), Hyun-Ju Park (Tekijä), Young Jae An (Tekijä), Joon Hun Choi (Tekijä), Geunyoung Cha (Tekijä), Hwa Jeong Lee (Tekijä), So-Jung Park (Tekijä), Purushottam M. Dewang (Tekijä), Dae-Kee Kim (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

A series of 2,4-disubstituted-5-(6-alkylpyridin-2-yl)-1H-imidazoles, 7a-c, 11a-h, and 16a-h has been synthesised and evaluated for their ALK5 inhibitory activity in an enzyme assay and in a cell-based luciferase reporter assay. Incorporation of a quinoxalin-6-yl moiety and a methylene linker at the...