Synthesis, biological evaluation and molecular modelling of 2,4-disubstituted-5-(6-alkylpyridin-2-yl)-1H-imidazoles as ALK5 inhibitors

• Main Authors: Myoung-Soon Park (Author), Hyun-Ju Park (Author), Young Jae An (Author), Joon Hun Choi (Author), Geunyoung Cha (Author), Hwa Jeong Lee (Author), So-Jung Park (Author), Purushottam M. Dewang (Author), Dae-Kee Kim (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A series of 2,4-disubstituted-5-(6-alkylpyridin-2-yl)-1H-imidazoles, 7a-c, 11a-h, and 16a-h has been synthesised and evaluated for their ALK5 inhibitory activity in an enzyme assay and in a cell-based luciferase reporter assay. Incorporation of a quinoxalin-6-yl moiety and a methylene linker at the...