Effect of hydrophobic extension of aryl enaminones and pyrazole-linked compounds combined with sulphonamide, sulfaguanidine, or carboxylic acid functionalities on carbonic anhydrase inhibitory potency and selectivity

Design and synthesis of three novel series of aryl enaminones (3a-f and 5a-c) and pyrazole (4a-c) linked compounds with sulphonamides, sulfaguanidine, or carboxylic acid functionalities were reported as carbonic anhydrase inhibitors (CAIs) using the "tail approach" strategy in their design...

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Main Authors: Heba Abdelrasheed Allam (Author), Mohamed E. Albakry (Author), Walaa R. Mahmoud (Author), Alessandro Bonardi (Author), Shaimaa A. Moussa (Author), Samy Mohamady (Author), Hatem A. Abdel-Aziz (Author), Claudiu T. Supuran (Author), Hany S. Ibrahim (Author)
Format: Book
Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
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