Inhibition of OGG1 ameliorates pulmonary fibrosis via preventing M2 macrophage polarization and activating PINK1-mediated mitophagy

• Main Authors: Wenjuan Wu (Author), Hongxia Jia (Author), Song Chen (Author), Xinran Ma (Author), Shuai Zhou (Author), Lingxiao Qiu (Author), Xinhui Wu (Author), Ping Li (Author), Heying Chu (Author), Guojun Zhang (Author)
• Format: Book
• Published: BMC, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background 8-Oxoguanine DNA glycosylase (OGG1), a well-known DNA repair enzyme, has been demonstrated to promote lung fibrosis, while the specific regulatory mechanism of OGG1 during pulmonary fibrosis remains unclarified. Methods A bleomycin (BLM)-induced mouse pulmonary fibrosis model was...