Aptamer-miRNA-212 Conjugate Sensitizes NSCLC Cells to TRAIL

• Main Authors: Margherita Iaboni (Author), Valentina Russo (Author), Raffaela Fontanella (Author), Giuseppina Roscigno (Author), Danilo Fiore (Author), Elvira Donnarumma (Author), Carla Lucia Esposito (Author), Cristina Quintavalle (Author), Paloma H Giangrande (Author), Vittorio de Franciscis (Author), Gerolama Condorelli (Author)
• Format: Book
• Published: Elsevier, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

TNF-related apoptosis-inducing ligand (TRAIL) is a promising antitumor agent for its remarkable ability to selectively induce apoptosis in cancer cells, without affecting the viability of healthy bystander cells. The TRAIL tumor suppressor pathway is deregulated in many human malignancies including...