In vitro and in silico studies of bis (indol-3-yl) methane derivatives as potential α-glucosidase and α-amylase inhibitors

In vitro and in silico studies of bis (indol-3-yl) methane derivatives as potential α-glucosidase and α-amylase inhibitors

In this paper, bis (indol-3-yl) methanes (BIMs) were synthesised and evaluated for their inhibitory activity against α-glucosidase and α-amylase. All synthesised compounds showed potential α-glucosidase and α-amylase inhibitory activities. Compounds 5 g (IC50: 7.54 ± 1.10 μM), 5e (IC50: 9.00 ± 0.97 ...

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Main Authors: Peng-Fei Zheng (Author), Zhuang Xiong (Author), Cui-ying Liao (Author), Xin Zhang (Author), Mei Feng (Author), Xiao-Zheng Wu (Author), Jing Lin (Author), Lin-Sheng Lei (Author), You-Cheng Zhang (Author), Shao-Hua Wang (Author), Xue-Tao Xu (Author)
Format: Book
Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
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