Synthesis, biological evaluation and theoretical studies of (E)-1-(4-sulfamoyl-phenylethyl)-3-arylidene-5-aryl-1H-pyrrol-2(3H)-ones as human carbonic anhydrase inhibitors

• Главные авторы: Farhat Ramzan (Автор), Syed Ayaz Nabi (Автор), Mehak Saba Lone (Автор), Alessandro Bonardi (Автор), Aabid Hamid (Автор), Sameena Bano (Автор), Kalicharan Sharma (Автор), Syed Shafi (Автор), Mohammed Samim (Автор), Kalim Javed (Автор), Claudiu T. Supuran (Автор)
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• Опубликовано: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Предметы: article
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A series of 20 newly designed (E)-1-(4-sulphamoylphenylethyl)-3-arylidene-5-aryl-1H-pyrrol-2(3H)-ones was synthesised and assessed as carbonic anhydrase (CA, EC 4.2.1.1) inhibitors towards four human isoforms of pharmaceutical interest, that is, hCA I, II, IX and XII. The compounds displayed low to...