Synthesis, biological evaluation and theoretical studies of (E)-1-(4-sulfamoyl-phenylethyl)-3-arylidene-5-aryl-1H-pyrrol-2(3H)-ones as human carbonic anhydrase inhibitors

• Main Authors: Farhat Ramzan (Author), Syed Ayaz Nabi (Author), Mehak Saba Lone (Author), Alessandro Bonardi (Author), Aabid Hamid (Author), Sameena Bano (Author), Kalicharan Sharma (Author), Syed Shafi (Author), Mohammed Samim (Author), Kalim Javed (Author), Claudiu T. Supuran (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A series of 20 newly designed (E)-1-(4-sulphamoylphenylethyl)-3-arylidene-5-aryl-1H-pyrrol-2(3H)-ones was synthesised and assessed as carbonic anhydrase (CA, EC 4.2.1.1) inhibitors towards four human isoforms of pharmaceutical interest, that is, hCA I, II, IX and XII. The compounds displayed low to...