Differentiation between temporary and real non-clearability of biotinylated IgG antibody by avidin in mice

• Main Authors: Shuping eDou (Author), John eVirostko (Author), Mary eRusckowski (Author), Dale eGreiner (Author), Alvin ePowers (Author), Guozheng eLiu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2014-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Although an increasing number of antibody conjugates are being used in the clinic, there remain many unmet needs in antibody targeting. Normal tissue background is one of the key issues that limits the therapeutic efficacy and detection sensitivity. Background reduction coupled with dose increase ma...