Arginase activity - a marker of disease status in patients with visceral leishmaniasis in ethiopia.

• Main Authors: Tamrat Abebe (Author), Yegnasew Takele (Author), Teklu Weldegebreal (Author), Tom Cloke (Author), Ellen Closs (Author), Camille Corset (Author), Asrat Hailu (Author), Workagegnehu Hailu (Author), Yifru Sisay (Author), Karina Corware (Author), Margaux Corset (Author), Manuel Modolell (Author), Markus Munder (Author), Fabienne Tacchini-Cottier (Author), Ingrid Müller (Author), Pascale Kropf (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The underlying mechanisms resulting in the profound immune suppression characteristic of human visceral leishmaniasis (VL) are not fully understood. Here, we tested the hypothesis that arginase, an enzyme associated with immunosuppression, is higher in patients with VL and contributes to impaired T...