QT PRODACT: Comparison of Non-clinical Studies for Drug-Induced Delay in Ventricular Repolarization and Their Role in Safety Evaluation in Humans

• Päätekijät: Takeshi Omata (Tekijä), Chieko Kasai (Tekijä), Munehiro Hashimoto (Tekijä), Toshiyasu Hombo (Tekijä), Keiji Yamamoto (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Elsevier, 2005-01-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Drug concentrations that would prolong repolarization parameters by 10%, including action potential duration (APD90, APD30-90), in in vitro assays using guinea-pig papillary muscle and QTc intervals in in vivo assays using conscious dogs, conscious monkeys, and anesthetized dogs were compared. Altho...