Microtubule-targeting drugs rescue axonal swellings in cortical neurons from spastin knockout mice

SUMMARY Mutations in SPG4, encoding the microtubule-severing protein spastin, are responsible for the most frequent form of hereditary spastic paraplegia (HSP), a heterogeneous group of genetic diseases characterized by degeneration of the corticospinal tracts. We previously reported that mice harbo...

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主要な著者: Coralie Fassier (著者), Anne Tarrade (著者), Leticia Peris (著者), Sabrina Courageot (著者), Philippe Mailly (著者), Cécile Dalard (著者), Stéphanie Delga (著者), Natacha Roblot (著者), Julien Lefèvre (著者), Didier Job (著者), Jamilé Hazan (著者), Patrick A. Curmi (著者), Judith Melki (著者)
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出版事項: The Company of Biologists, 2013-01-01T00:00:00Z.
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