Microtubule-targeting drugs rescue axonal swellings in cortical neurons from spastin knockout mice

• मुख्य लेखकों: Coralie Fassier (लेखक), Anne Tarrade (लेखक), Leticia Peris (लेखक), Sabrina Courageot (लेखक), Philippe Mailly (लेखक), Cécile Dalard (लेखक), Stéphanie Delga (लेखक), Natacha Roblot (लेखक), Julien Lefèvre (लेखक), Didier Job (लेखक), Jamilé Hazan (लेखक), Patrick A. Curmi (लेखक), Judith Melki (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: The Company of Biologists, 2013-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

SUMMARY Mutations in SPG4, encoding the microtubule-severing protein spastin, are responsible for the most frequent form of hereditary spastic paraplegia (HSP), a heterogeneous group of genetic diseases characterized by degeneration of the corticospinal tracts. We previously reported that mice harbo...