Microtubule-targeting drugs rescue axonal swellings in cortical neurons from spastin knockout mice

• Main Authors: Coralie Fassier (Author), Anne Tarrade (Author), Leticia Peris (Author), Sabrina Courageot (Author), Philippe Mailly (Author), Cécile Dalard (Author), Stéphanie Delga (Author), Natacha Roblot (Author), Julien Lefèvre (Author), Didier Job (Author), Jamilé Hazan (Author), Patrick A. Curmi (Author), Judith Melki (Author)
• Format: Book
• Published: The Company of Biologists, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY Mutations in SPG4, encoding the microtubule-severing protein spastin, are responsible for the most frequent form of hereditary spastic paraplegia (HSP), a heterogeneous group of genetic diseases characterized by degeneration of the corticospinal tracts. We previously reported that mice harbo...