Mechanism of action of hepatitis B virus S antigen transport-inhibiting oligonucleotide polymer, STOPS, molecules

• Main Authors: C. Cheng Kao (Author), Yuchun Nie (Author), Suping Ren (Author), N. Tilani T.S. De Costa (Author), Rajendra K. Pandey (Author), Jin Hong (Author), David B. Smith (Author), Julian A. Symons (Author), Leonid Beigelman (Author), Lawrence M. Blatt (Author)
• Format: Book
• Published: Elsevier, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A functional cure of chronic hepatitis B requires eliminating the hepatitis B virus (HBV)-encoded surface antigen (HBsAg), which can suppress immune responses. STOPS are phosphorothioated single-stranded oligonucleotides containing novel chemistries that significantly reduce HBsAgs produced by HBV-i...