Intravenous anti-influenza drug oseltamivir will not induce torsade de pointes: Evidences from proarrhythmia model and action-potential assay

• Main Authors: Yuji Nakamura (Author), Rieko Sasaki (Author), Xin Cao (Author), Takeshi Wada (Author), Shogo Hamaguchi (Author), Hiroko Izumi-Nakaseko (Author), Kentaro Ando (Author), Hikaru Tanaka (Author), Akira Takahara (Author), Atsushi Sugiyama (Author)
• Format: Book
• Published: Elsevier, 2016-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We evaluated proarrhythmic risk of intravenous oseltamivir with chronic atrioventricular block canine model (n = 4) and action-potential assay on guinea-pig right ventricle (n = 5). Oseltamivir in doses of 3-30 mg/kg, i.v. did not induce torsade de pointes in the canine model, whereas that in concen...