Synthesis, docking study, and in vitro anticancer evaluation of new flufenamic acid derivatives

• Main Authors: Ammar I. Al-Bayati (Author), Ammar A. Razzak Mahmood (Author), Zainab A. Al-Mazaydeh (Author), Majdoleen S. Rammaha (Author), Rheda I. Al-bayati (Author), Fatima Alsoubani (Author), Lubna H. Tahtamouni (Author)
• Format: Book
• Published: Pensoft Publishers, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Novel compounds (6-10) were synthesized and confirmed by spectroscopic analysis, including AT-IR, 1HNMR and CHNS. Their cytotoxic effect was evaluated by MTT assay against two cancer cell lines and two normal cell types. Compound 7 exhibited anticancer activity against MCF-7 breast cancer cell line...