Liquid Crystalline Nanoparticles for Nasal Delivery of Rosuvastatin: Implications on Therapeutic Efficacy in Management of Epilepsy

• Main Authors: Mohammad Zubair Ahmed (Author), Urooj A. Khan (Author), Abdul Haye (Author), Nidhi B. Agarwal (Author), Nabil A. Alhakamy (Author), Hani A. Alhadrami (Author), Musarrat Husain Warsi (Author), Gaurav K. Jain (Author)
• Format: Book
• Published: MDPI AG, 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In the present study we investigated the protective role of intranasal rosuvastatin liquid crystalline nanoparticles (Ros-LCNPs) against pentylenetetrazole (PTZ) induced seizures, increasing current electroshock (ICES) induced seizures, and PTZ-induced status epilepticus. From the dose titration stu...