Hepatocyte cholesterol content modulates glucagon receptor signalling

• Main Authors: Emma Rose McGlone (Author), T. Bertie Ansell (Author), Cecilia Dunsterville (Author), Wanling Song (Author), David Carling (Author), Alejandra Tomas (Author), Stephen R. Bloom (Author), Mark S.P. Sansom (Author), Tricia Tan (Author), Ben Jones (Author)
• Format: Book
• Published: Elsevier, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Structured abstract: Objective: To determine whether glucagon receptor (GCGR) actions are modulated by cellular cholesterol levels. Methods: We determined the effects of experimental cholesterol depletion and loading on glucagon-mediated cAMP production, ligand internalisation and glucose production...