Impedance-Based Phenotypic Readout of Transporter Function: A Case for Glutamate Transporters

• Main Authors: Hubert J. Sijben (Author), Laura Dall' Acqua (Author), Rongfang Liu (Author), Abigail Jarret (Author), Eirini Christodoulaki (Author), Svenja Onstein (Author), Gernot Wolf (Author), Simone J. Verburgt (Author), Sylvia E. Le Dévédec (Author), Tabea Wiedmer (Author), Giulio Superti-Furga (Author), Adriaan P. IJzerman (Author), Laura H. Heitman (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Excitatory amino acid transporters (EAAT/SLC1) mediate Na+-dependent uptake of extracellular glutamate and are potential drug targets for neurological disorders. Conventional methods to assess glutamate transport in vitro are based on radiolabels, fluorescent dyes or electrophysiology, which potenti...