Design and development of novel, short, stable dynorphin-based opioid agonists for safer analgesic therapy

• Main Authors: Rink-Jan Lohman (Author), Karnaker Reddy Tupally (Author), Ajit Kandale (Author), Peter J. Cabot (Author), Harendra S. Parekh (Author)
• Format: Knjiga
• Izdano: Frontiers Media S.A., 2023-03-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

Kappa opioid receptors have exceptional potential as an analgesic target, seemingly devoid of many problematic Mu receptor side-effects. Kappa-selective, small molecule pharmaceutical agents have been developed, but centrally mediated side-effects limit clinical translation. We modify endogenous dyn...