N-Acetylcysteine for Preventing Acetaminophen-Induced Liver Injury: A Comprehensive Review

• Main Authors: Anna Licata (Author), Maria Giovanna Minissale (Author), Simona Stankevičiūtė (Author), Judith Sanabria-Cabrera (Author), Maria Isabel Lucena (Author), Raul J Andrade (Author), Piero Luigi Almasio (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aims: N-Acetylcysteine (NAC) is used as an antidote in acetaminophen (APAP) overdose to prevent and mitigate drug-induced liver injury (DILI). Our objective was to systematically review evidence of the use of NAC as a therapeutic option for APAP overdose and APAP-related DILI in order to define the...