Stereoselectivity of Aldose Reductase in the Reduction of Glutathionyl-Hydroxynonanal Adduct

• Main Authors: Francesco Balestri (Author), Vito Barracco (Author), Giovanni Renzone (Author), Tiziano Tuccinardi (Author), Christian Silvio Pomelli (Author), Mario Cappiello (Author), Marco Lessi (Author), Rossella Rotondo (Author), Fabio Bellina (Author), Andrea Scaloni (Author), Umberto Mura (Author), Antonella Del Corso (Author), Roberta Moschini (Author)
• Format: Book
• Published: MDPI AG, 2019-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The formation of the adduct between the lipid peroxidation product 4-hydroxy-2-nonenal (HNE) and glutathione, which leads to the generation of 3-glutathionyl-4-hydroxynonane (GSHNE), is one of the main routes of HNE detoxification. The aldo-keto reductase AKR1B1 is involved in the reduction of the a...