The impact of immunogenicity on therapeutic antibody pharmacokinetics: A preclinical evaluation of the effect of immune complex formation and antibody effector function on clearance

• Main Authors: Eugenia Opolka-Hoffmann (Author), Gregor Jordan (Author), Michael Otteneder (Author), Robin Kieferle (Author), Martin Lechmann (Author), Gerhard Winter (Author), Roland F. Staack (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The occurrence of an immune response against therapeutic proteins poses a major risk for the development of biologics and for successful treatment of patients. Generation of anti-drug antibodies (ADAs) can lead to formation of immune complexes (ICs), consisting of drug and ADAs, with potential impac...