The impact of immunogenicity on therapeutic antibody pharmacokinetics: A preclinical evaluation of the effect of immune complex formation and antibody effector function on clearance

• Hoofdauteurs: Eugenia Opolka-Hoffmann (Auteur), Gregor Jordan (Auteur), Michael Otteneder (Auteur), Robin Kieferle (Auteur), Martin Lechmann (Auteur), Gerhard Winter (Auteur), Roland F. Staack (Auteur)
• Formaat: Boek
• Gepubliceerd in: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

The occurrence of an immune response against therapeutic proteins poses a major risk for the development of biologics and for successful treatment of patients. Generation of anti-drug antibodies (ADAs) can lead to formation of immune complexes (ICs), consisting of drug and ADAs, with potential impac...