Nano-Polyplexes Mediated Transfection of Runx2-shRNA Mitigates the Osteodifferentiation of Human Valvular Interstitial Cells

• Main Authors: Geanina Voicu (Author), Daniela Rebleanu (Author), Cristina Ana Constantinescu (Author), Elena Valeria Fuior (Author), Letitia Ciortan (Author), Ionel Droc (Author), Cristina Mariana Uritu (Author), Mariana Pinteala (Author), Ileana Manduteanu (Author), Maya Simionescu (Author), Manuela Calin (Author)
• Format: Book
• Published: MDPI AG, 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Calcific aortic valve disease (CAVD) is a progressive disorder that increases in prevalence with age. An important role in aortic valve calcification is played by valvular interstitial cells (VIC), that with age or in pathological conditions acquire an osteoblast-like phenotype that advances the dis...