Nano-Polyplexes Mediated Transfection of Runx2-shRNA Mitigates the Osteodifferentiation of Human Valvular Interstitial Cells

• Главные авторы: Geanina Voicu (Автор), Daniela Rebleanu (Автор), Cristina Ana Constantinescu (Автор), Elena Valeria Fuior (Автор), Letitia Ciortan (Автор), Ionel Droc (Автор), Cristina Mariana Uritu (Автор), Mariana Pinteala (Автор), Ileana Manduteanu (Автор), Maya Simionescu (Автор), Manuela Calin (Автор)
• Формат: ‌
• Опубликовано: MDPI AG, 2020-06-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

Calcific aortic valve disease (CAVD) is a progressive disorder that increases in prevalence with age. An important role in aortic valve calcification is played by valvular interstitial cells (VIC), that with age or in pathological conditions acquire an osteoblast-like phenotype that advances the dis...