Allogeneic ABCB5+ Mesenchymal Stem Cells for Treatment-Refractory Chronic Venous Ulcers: A Phase I/IIa Clinical Trial

• मुख्य लेखकों: Andreas Kerstan (लेखक), Kathrin Dieter (लेखक), Elke Niebergall-Roth (लेखक), Ann-Kathrin Dachtler (लेखक), Korinna Kraft (लेखक), Markus Stücker (लेखक), Georg Daeschlein (लेखक), Michael Jünger (लेखक), Tobias Görge (लेखक), Ulrich Meyer-Pannwitt (लेखक), Cornelia Erfurt-Berge (लेखक), Charlotte von Engelhardt (लेखक), Andreas Klare (लेखक), Christiane Pfeiffer (लेखक), Jasmina Esterlechner (लेखक), Hannes M. Schröder (लेखक), Martin Gasser (लेखक), Ana M. Waaga-Gasser (लेखक), Matthias Goebeler (लेखक), Seda Ballikaya (लेखक), Samar Sadeghi (लेखक), George F. Murphy (लेखक), Dennis P. Orgill (लेखक), Natasha Y. Frank (लेखक), Christoph Ganss (लेखक), Karin Scharffetter-Kochanek (लेखक), Markus H. Frank (लेखक), Mark A. Kluth (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2022-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

A significant number of chronic venous ulcers (CVUs) fail to heal despite guideline-conform standards of care. Skin-derived ABCB5+ mesenchymal stem cells can dampen the sustained IL-1β‒driven inflammation present in chronic wounds. On the basis of their wound healing‒facilitating effects in a mouse...