SIRT6 as a key event linking P53 and NRF2 counteracts APAP-induced hepatotoxicity through inhibiting oxidative stress and promoting hepatocyte proliferation

• Main Authors: Yanying Zhou (Author), Xiaomei Fan (Author), Tingying Jiao (Author), Wenzhou Li (Author), Panpan Chen (Author), Yiming Jiang (Author), Jiahong Sun (Author), Yixin Chen (Author), Pan Chen (Author), Lihuan Guan (Author), Yajie Wen (Author), Min Huang (Author), Huichang Bi (Author)
• Format: Book
• Published: Elsevier, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Acetaminophen (APAP) overdose is the leading cause of drug-induced liver injury, and its prognosis depends on the balance between hepatocyte death and regeneration. Sirtuin 6 (SIRT6) has been reported to protect against oxidative stress-associated DNA damage. But whether SIRT6 regulates APAP-induced...