The Gene Signature of Activated M-CSF-Primed Human Monocyte-Derived Macrophages Is IL-10-Dependent

• Main Authors: Víctor D. Cuevas (Author), Miriam Simón-Fuentes (Author), Emmanuel Orta-Zavalza (Author), Rafael Samaniego (Author), Paloma Sánchez-Mateos (Author), María Escribese (Author), Francisco J. Cimas (Author), Matilde Bustos (Author), Mario Pérez-Diego (Author), Alberto Ocaña (Author), Ángeles Domínguez-Soto (Author), Miguel A. Vega (Author), Ángel L. Corbí (Author)
• Format: Book
• Published: Karger Publishers, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

During inflammatory responses, monocytes are recruited into inflamed tissues, where they become monocyte-derived macrophages and acquire pro-inflammatory and tissue-damaging effects in response to the surrounding environment. In fact, monocyte-derived macrophage subsets are major pathogenic cells in...