Benidipine impairs innate immunity converting sublethal to lethal infections in a murine model of spotted fever rickettsiosis.

• Main Authors: Andrés F Londoño (Author), Jennifer M Farner (Author), Marlon Dillon (Author), Dennis J Grab (Author), Yuri Kim (Author), Diana G Scorpio (Author), J Stephen Dumler (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Spotted fever group rickettsiae are tick-borne obligate intracellular bacteria that infect microvascular endothelial cells. Humans and mammalian infection results in endothelial cell barrier dysfunction and increased vascular permeability. We previously demonstrated that treatment of Rickettsia park...