Expanding the Repertoire of Target Sites for Zinc Finger Nuclease-mediated Genome Modification

• Egile Nagusiak: Kimberly A Wilson (Egilea), Abbye E McEwen (Egilea), Shondra M Pruett-Miller (Egilea), Jiuli Zhang (Egilea), Eric J Kildebeck (Egilea), Matthew H Porteus (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2013-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Recent studies have shown that zinc finger nucleases (ZFNs) are powerful reagents for making site-specific genomic modifications. The generic structure of these enzymes includes a ZF DNA-binding domain and nuclease domain (Fn) are separated by an amino acid "linker" and cut genomic DNA at...