Synthesis of a New Phenyl Chlormethine-Quinazoline Derivative, a Potential Anti-Cancer Agent, Induced Apoptosis in Hepatocellular Carcinoma Through Mediating Sirt1/Caspase 3 Signaling Pathway

Quinazoline derivatives display multiple pharmacological activities and target various biological receptors. Based on the skeleton of quinazoline core, we designed and synthesized three new quinazoline-phenyl chlormethine conjugates (I-III) bearing a Schiff base (C = N) linker, and investigated thei...

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Main Authors: Jia-jia Lv (Author), Wen-ting Song (Author), Xin-min Li (Author), Jian-mei Gao (Author), Ze-li Yuan (Author)
Format: Book
Published: Frontiers Media S.A., 2020-06-01T00:00:00Z.
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