Disease-associated alleles in genome-wide association studies are enriched for derived low frequency alleles relative to HapMap and neutral expectations

• Hovedforfatter: Lachance Joseph (Author)
• Format: Bog
• Udgivet: BMC, 2010-12-01T00:00:00Z.
• Fag: article
• Online adgang: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Genome-wide association studies give insight into the genetic basis of common diseases. An open question is whether the allele frequency distributions and ancestral vs. derived states of disease-associated alleles differ from the res...