Population pharmacokinetics and exposure‐response modeling analyses of guselkumab in patients with psoriatic arthritis

• Main Authors: Yang Chen (Author), Xin Miao (Author), Chyi‐Hung Hsu (Author), Yanli Zhuang (Author), Alexa Kollmeier (Author), Zhenhua Xu (Author), Honghui Zhou (Author), Amarnath Sharma (Author)
• Format: Book
• Published: Wiley, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Guselkumab is an anti‐interleukin‐23 human monoclonal antibody effective in treating psoriatic arthritis (PsA). To characterize the pharmacokinetics (PKs) and exposure‐response relationship of guselkumab in PsA, population PKs, and exposure‐response modeling, analyses were conducted using d...