Characterization of the absorption, metabolism, excretion, and mass balance of gefapixant in humans

• Main Authors: Jesse C. Nussbaum (Author), Azher Hussain (Author), Bennett Ma (Author), K. Chris Min (Author), Qing Chen (Author), Charles Tomek (Author), Marian Iwamoto (Author), S. Aubrey Stoch (Author)
• Format: Book
• Published: Wiley, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Gefapixant (MK‐7264) is a first‐in‐class, selective antagonist of the P2X3 purinergic receptor currently being investigated as a therapeutic agent for the treatment of refractory or unexplained chronic cough. In non‐clinical studies, gefapixant was eliminated primarily by renal excretion of...