Dendritic cell combination therapy reduces the toxicity of triptolide and ameliorates colitis in murine models

• Main Authors: Quan Rao (Author), Guang-chao Ma (Author), Hao Wu (Author), Meng Li (Author), Wei Xu (Author), Guo-jun Wang (Author), Dong Wang (Author), Cong-en Zhang (Author), Zhi-jie Ma (Author), Zhong-tao Zhang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Triptolide (TP) exerts a promising effect in the treatment of ulcerative colitis (UC). However, its toxicity seriously hinders its application in the clinic. Previous studies indicated that dendritic cells (DCs) are the main target through which TP exerts its immunoregulatory effect. Thus, we design...