Surfactant-Assisted Distal Pulmonary Distribution of Budesonide Revealed by Mass Spectrometry Imaging

• Main Authors: Riccardo Zecchi (Author), Pietro Franceschi (Author), Laura Tigli (Author), Barbara Pioselli (Author), Valentina Mileo (Author), Xabier Murgia (Author), Fabrizio Salomone (Author), Giuseppe Pieraccini (Author), Haruo Usada (Author), Augusto F. Schmidt (Author), Noah H. Hillman (Author), Matthew W. Kemp (Author), Alan H. Jobe (Author)
• Format: Book
• Published: MDPI AG, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Direct lung administration of budesonide in combination with surfactant reduces the incidence of bronchopulmonary dysplasia. Although the therapy is currently undergoing clinical development, the lung distribution of budesonide throughout the premature neonatal lung has not yet been investigated. He...