Antibody-Antisense Oligonucleotide Conjugate Downregulates a Key Gene in Glioblastoma Stem Cells

• Main Authors: Amy E. Arnold (Author), Elise Malek-Adamian (Author), Phuong U. Le (Author), Anika Meng (Author), Saúl Martínez-Montero (Author), Kevin Petrecca (Author), Masad J. Damha (Author), Molly S. Shoichet (Author)
• Format: Book
• Published: Elsevier, 2018-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Glioblastoma stem cells (GSCs) are invasive, treatment-resistant brain cancer cells that express downregulated in renal cell carcinoma (DRR), also called FAM107A, a genetic driver of GSC invasion. We developed antibody-antisense oligonucleotide (AON) conjugates to target and reduce DRR/FAM107A expre...