Discovery of a potent and highly selective inhibitor of SIRT6 against pancreatic cancer metastasis in vivo

• Main Authors: Xinyuan Xu (Author), Qian Zhang (Author), Xufeng Wang (Author), Jing Jin (Author), Chengwei Wu (Author), Li Feng (Author), Xiuyan Yang (Author), Mingzhu Zhao (Author), Yingyi Chen (Author), Shaoyong Lu (Author), Zhen Zheng (Author), Xiaobing Lan (Author), Yi Wang (Author), Yan Zheng (Author), Xuefeng Lu (Author), Qiufen Zhang (Author), Jian Zhang (Author)
• Format: Book
• Published: Elsevier, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pancreatic cancer, one of the most aggressive malignancies, has no effective treatment due to the lack of targets and drugs related to tumour metastasis. SIRT6 can promote the migration of pancreatic cancer and could be a potential target for antimetastasis of pancreatic cancer. However, highly sele...