CTLA4-Ig interferes and downregulates the proinflammatory activities of rheumatoid synovial macrophages in monoculture

• Main Authors: L. Felli (Author), L. Molfetta (Author), P. Clerico (Author), P.F. Triolo (Author), B. Villaggio (Author), B. Seriolo (Author), A. Sulli (Author), P. Montagna (Author), S. Soldano (Author), R. Brizzolara (Author), M. Cutolo (Author)
• Format: Book
• Published: PAGEPress Publications, 2011-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: CTLA4-Ig, a biologic agent employed in rheumatoid arthritis (RA) treatment, downregulates the immune response and exerts anti-inflammatory effects acting on different cells including dendritic/T cells interaction and directly on osteoclasts. We investigated the anti-inflammatory effects o...