BAY 60-6583 Enhances the Antitumor Function of Chimeric Antigen Receptor-Modified T Cells Independent of the Adenosine A2b Receptor

• Main Authors: Jiaxing Tang (Author), Yan Zou (Author), Long Li (Author), Fengping Lu (Author), Hongtao Xu (Author), Pengxuan Ren (Author), Fang Bai (Author), Gabriele Niedermann (Author), Xuekai Zhu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chimeric antigen receptor (CAR) T cells are powerful in eradicating hematological malignancies, but their efficacy is limited in treating solid tumors. One of the barriers is the immunosuppressive response induced by immunomodulatory signaling pathways. Pharmacological targeting of these immunosuppr...