Anti-HMGB1 Neutralizing Antibody Ameliorates Neutrophilic Airway Inflammation by Suppressing Dendritic Cell-Mediated Th17 Polarization

• Главные авторы: Fang Zhang (Автор), Gang Huang (Автор), Bo Hu (Автор), Li-Ping Fang (Автор), E-Hong Cao (Автор), Xiao-Feng Xin (Автор), Yong Song (Автор), Yi Shi (Автор)
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• Опубликовано: Hindawi Limited, 2014-01-01T00:00:00Z.
• Предметы: article
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We demonstrate that high mobility group box 1 protein (HMGB1) directs Th17 skewing by regulating dendritic cell (DC) function. First, our in vitro studies reveal that recombinant HMGB1 (rHMGB1) activates myeloid DCs to produce IL-23 in vitro, and rHMGB1-activated DCs prime naïve lymphocytes to prod...