Anti-HMGB1 Neutralizing Antibody Ameliorates Neutrophilic Airway Inflammation by Suppressing Dendritic Cell-Mediated Th17 Polarization

• Hoofdauteurs: Fang Zhang (Auteur), Gang Huang (Auteur), Bo Hu (Auteur), Li-Ping Fang (Auteur), E-Hong Cao (Auteur), Xiao-Feng Xin (Auteur), Yong Song (Auteur), Yi Shi (Auteur)
• Formaat: Boek
• Gepubliceerd in: Hindawi Limited, 2014-01-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

We demonstrate that high mobility group box 1 protein (HMGB1) directs Th17 skewing by regulating dendritic cell (DC) function. First, our in vitro studies reveal that recombinant HMGB1 (rHMGB1) activates myeloid DCs to produce IL-23 in vitro, and rHMGB1-activated DCs prime naïve lymphocytes to prod...